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Term of the Day

Natural History Study

A natural history study is a preplanned intended to track the course of the disease. Its purpose is to identify demographic, genetic, environmental, and other variables (e.g., treatment modalities, concomitant medications) that correlate with the disease’s development and outcomes. Natural history studies are likely to include patients receiving the current standard of care and/or emergent care, which may alter some manifestations of the disease.


Central imaging

In a clinical trial, central imaging refers to the evaluation and interpretation of medical imaging data by a central review facility rather than the local site investigator. This central review facility typically consists of a team of trained radiologists or imaging experts who are responsible for assessing and analyzing imaging data from all participants in the clinical trial.Central imaging is often used in clinical trials to ensure that imaging data is analyzed in a consistent and standardized manner, minimizing potential biases that may arise from local site variability in imaging interpretation. This can improve the accuracy and reliability of imaging data in clinical trials, leading to more meaningful